Nature：华人科学家施一公揭示蛋白质相互作用调控细胞凋亡的结构学基础
生物谷报道：本期Nature上报道了华人科学家施一公（著名的结构生物学家）发现了线虫中两种蛋白CED-4和CED-9（与高等生物中的caspase家族一致）相互作用的结构学基础，从而从结构学水平上揭示了它们共同导致细胞凋亡的机制。
这篇文章突破了两种蛋白质相互作用的结构学基础的研究，从而从结构上揭示蛋白质间相互作用。
a, The CED-4a−CED-4b interactions consist of a primary (orange circle) and a secondary (magenta circle) site. b, A stereo view of the primary interface of the CED-4 dimer. Helices 
8, 11 and 11b, from CED-4b, stack against the CARD and /
domains of CED-4a. c, ATP and magnesium are buried in CED-4. ATP molecules and magnesium ions are highlighted in yellow and magenta, respectively. d, A stereo view of ATP coordination in CED-4. Hydrogen bonds are represented by red dashed lines. ATP is shown in orange, with nitrogen and oxygen atoms shown in blue and red, respectively.
原文来源：
Nieng Yan, Jijie Chai, Eui Seung Lee, Lichuan Gu, Qun Liu, Jiaqing He, Jia-Wei Wu, David Kokel, Huilin Li, Quan Hao, Ding Xue and Yigong Shi. Structure of the CED-4−CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans, Nature 437, 831-837 (6 October 2005)
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