Neurology：高龄女性比男性更易患痴呆症
根据一项发表在2008年7月2日的《神经病学》（Neurology）杂志网络版的一项研究，年龄超过90岁的女性比年龄超过90岁的男性患上痴呆的可能性显著更高。研究表明男性和女性患痴呆的风险都会从65岁到85岁的年龄段增加，但是这项最新的研究是少数针对年龄超过90岁人群的一项研究。
该研究的作者、加州大学欧文分校的Maria Corrada博士说：“尽管男性通常不会活得像女性一样长久，但那些确实活到了90岁的男性看上去患痴呆的可能性小得多，而当他们患上痴呆的时候，他们的生存时间更短。”
科学家回顾了对约900名90岁及以上人们的一项分析。在这些人中间，375人患有痴呆。该研究发现，和男性相比，女性在超过90岁之后患上痴呆的可能性几乎是男性的两倍。这些结果还表明女性每过5年患上痴呆的可能性就会加倍，但是男性没有这种情况。
“随着越来越多的人们年龄达到90岁，我们的发现提供了进一步的证据，证明了还需要做更多的努力，为照顾数量不断增长的有记忆问题的高龄人群提供足够的资源”，Corrada说。
此外，该研究发现受过高等教育的女性看上去比受教育更少的女性患痴呆的可能性至多少45%。（生物谷Bioon.com）
生物谷推荐原始出处：
Neurology，doi:10.1212/01.wnl.0000310773.65918.cd，M. M. Corrada，C. H. Kawas
Prevalence of dementia after age 90. Results from The 90+ Study
M. M. Corrada ScD*,
From the Department of Neurology (M.M.C., C.H.K.), Department of Neurobiology & Behavior (C.H.K.), and Institute for Brain Aging and Dementia (M.M.C., D.B., C.H.K.), University of California Irvine; Department of Biostatistics (R.B.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; and Department of Preventive Medicine (A.P.-H.), Keck School of Medicine, University of Southern California, CA.
* To whom correspondence should be addressed. E-mail: mcorrada@uci.edu .
Background: Although the prevalence of dementia increases with age from ages 65 to 85, whether this increase continues after age 90 is unclear. Most studies reporting on dementia prevalence do not have sufficient participants to estimate prevalence for specific ages and sexes above age 90. Here, we estimate age- and sex-specific prevalence of all-cause dementia in the oldest-old, those aged 90 and older.
Methods: Participants are 911 elderly from The 90+ Study, a population-based study of aging and dementia in people aged 90 and above. Dementia was diagnosed using in-person examinations as well as telephone and informant questionnaires.
Results: The overall prevalence of all-cause dementia was higher in women (45%, 95% CI = 41.5–49.0) than men (28%, 95% CI = 21.7–34.2). Among women, prevalence increased with age after age 90, essentially doubling every 5 years. A lower prevalence of dementia was significantly associated with higher education in women but not in men.
Conclusions: In a very large sample of participants aged 90 and older, prevalence of all-cause dementia doubled every 5 years for women but not men.
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