2008-3-28 12:41:32

J.Pediatrics：早期诊断胎儿酒精综合征的新方法

患有胎儿酒精综合征的孩子很可能在后来的生活中出现严重的心理和行为问题，例如辍学、失业和犯罪等。研究表明，早期干预可以有效减少胎儿酒精综合征的危害。不幸的是，胎儿酒精综合征的早期诊断常常无法实现，尤其是在B超无法显示胎儿某些部位发育特征的情况下。美国科学家的一项最新研究为胎儿酒精综合征得早期诊断带来了希望。相关论文发表在2008年1月的爱思唯尔期刊《儿科学杂志》（The Journal of Pediatrics）在线版上。

文章第一作者Jennifer Peterson博士和同事搜集了216名婴儿的数据，这些婴儿的母亲在妊娠期里都存在不同程度的饮酒行为。研究人员测量了新生婴儿第一次肠道运动过程中的脂肪酸乙酯（fatty acid ethyl esters，酒精在消化系统中分解的产物之一）水平。此后，研究人员又分别在6个月、1岁和2岁时对孩子进行进一步的检查。

研究人员发现，第一次肠道运动过程中的脂肪酸乙酯水平高的婴儿出现发育异常的风险更大。Peterson博士说：“婴儿的脂肪酸乙酯水平越高，在2岁前出现智力与精神发育不良的风险越大。”

新的研究表明，测量新生婴儿第一次肠道运动过程中的脂肪酸乙酯水平可能是准确诊断胎儿酒精综合征的一种有效方法，这将使胎儿酒精综合征早发现早治疗成为可能。（科学网荔涛/编译）

生物谷推荐原始出处：

(The Journal of Pediatrics)，doi:10.1016/j.jpeds.2007.11.009，Jennifer Peterson, Cynthia F. Bearer

Fatty Acid Ethyl Esters in Meconium are Associated with Poorer Neurodevelopmental Outcomes to Two Years of Age

Jennifer Peterson MD^,^§^,^,, H. Lester Kirchner PhD, Wei Xue MS, Sonia Minnes PhD^†, Lynn T. Singer PhD and Cynthia F. Bearer MD, PhD^,^‡^,

^†Division of General Medical Sciences (S.M.), Case Western Reserve University School of Medicine
^‡Mary Ann Swetland Center for Environmental Health (C.B.), Case Western Reserve University School of Medicine
Department of Pediatrics (J.P., L.K., W.X., L.S., C.B.), Case Western Reserve University School of Medicine
Division of Neonatology (C.B.), Rainbow Babies and Children's Hospital, Cleveland, Ohio
^§Department of Neonatology (J.P.), Cleveland Clinic, Cleveland, Ohio
Received 20 February 2007; revised 24 July 2007; accepted 8 November 2007. Available online 10 January 2008.

Objective

To determine the relationship between fatty acid ethyl esters (FAEE) in meconium and neurodevelopment in infants exposed to alcohol in utero at 6.5 months, 1 year, and 2 years of age.

Study design

A secondary analysis of a prospective cohort of mothers at high risk and their infants recruited after admission to a labor and delivery unit. Mothers were screened for drug and alcohol use during pregnancy by clinical interview and urine screening. Meconium was analyzed for FAEE in 216 newborn infants. Outcome measures included the Bayley Scales of Infant Development Mental (MDI) and Psychomotor (PDI) Developmental Index scores in infants at 6.5 months, 1 year, and 2 years of age.

Results

After controlling for prenatal visits and maternal factors, increasing concentrations of FAEE were significantly associated with poorer mental and psychomotor development (β ± standard error) at all follow-up visits: ethyl myristate (MDI −2.46 ± 1.24, P = .05; PDI −3.88 ± 1.67, P = .02), ethyl oleate (MDI −1.94 ± 0.65, P < .01; PDI −2.60 ± 0.93, P < .01), ethyl linoleate (MDI −1.92 ± 0.60, P < .01; PDI −2.28 ± 0.84, P < .01), ethyl linolenate (MDI −1.99 ± 0.74, P < .01; PDI −2.98 ± 1.04, P < .01), and ethyl arachidonate (MDI −2.40 ± 1.11, P = .03; PDI −3.32 ± 1.51, P = .03).