Anesthesiology：硫化氢休眠老鼠无副作用

（来源：中国生命科学论坛 谷友：夜深沉）

人们进入数百年的梦境，当他醒来时却发现自己身处另一个世界。这种人体休眠实验现在能否实现呢？

很不幸的是之前使人体进入休眠状态的科学方法十分困难，实验者至少要在头部塞满防冻剂和液态氮延缓人体的新陈代谢，此外，还有更为极端的一种方法——将人体的血液排干，然后进行冷冻。由此看来人们如果要想进入休眠状态，在未来的时空中苏醒是不可能的。目前，美国科学家为人体休眠实验带来了新的希望，马萨诸塞州中心医院的研究人员将这项研究发表在《麻醉学》（Anesthesiology）期刊上。他们使用一种臭鸡蛋气味的硫化氢气体能够完全中断老鼠的新陈代谢，几分钟之后当老鼠苏醒时没有表现出任何副作用。

早期研究显示硫化氢气体具有减缓新陈代谢的功能，但是科学家们并不能确定究竟是采用硫化氢气体还是降低体温能够实现生命体新陈代谢停止。为了鉴别两种方法的有效性，马萨诸塞州中心医院的研究人员分别对两组实验老鼠进行了测试，第一组老鼠先降低体温再放在室温条件下逐渐加热；第二组老鼠进行硫化氢气体吸入。两组实验同样达到了新陈代谢延缓的效果，但硫化氢气体方法却更为有效可行。

科学家下一步计划对大型动物进行研究，观测比老鼠更复杂的物种维持一段时间休眠时是否会出现身体损伤。这项研究可以长期地应用于远太空旅行、手术和战场治疗中的器官保存。(来源：新浪科技 魏冬)

生物谷推荐原始出处：

（Anesthesiology），108(4):659-668, April 2008，Volpato Gian Paolo，Zapol Warren

Laboratory Investigations

Abstract:
Background: Breathing hydrogen sulfide (H2S) has been reported to induce a suspended animation-like state with hypothermia and a concomitant metabolic reduction in rodents. However, the impact of H2S breathing on cardiovascular function remains incompletely understood. In this study, the authors investigated the cardiovascular and metabolic effects of inhaled H2S in a murine model.

Methods: The impact of breathing H2S on cardiovascular function was examined using telemetry and echocardiography in awake mice. The effects of breathing H2S on carbon dioxide production and oxygen consumption were measured at room temperature and in a warmed environment.

Results: Breathing H2S at 80 parts per million by volume at 27[degrees]C ambient temperature for 6 h markedly reduced heart rate, core body temperature, respiratory rate, and physical activity, whereas blood pressure remained unchanged. Echocardiography demonstrated that H2S exposure decreased both heart rate and cardiac output but preserved stroke volume. Breathing H2S for 6 h at 35[degrees]C ambient temperature (to prevent hypothermia) decreased heart rate, physical activity, respiratory rate, and cardiac output without altering stroke volume or body temperature. H2S breathing seems to induce bradycardia by depressing sinus node activity. Breathing H2S for 30 min decreased whole body oxygen consumption and carbon dioxide production at either 27[degrees] or 35[degrees]C ambient temperature. Both parameters returned to baseline levels within 10 min after the cessation of H2S breathing.

Conclusions: Inhalation of H2S at either 27[degrees] or 35[degrees]C reversibly depresses cardiovascular function without changing blood pressure in mice. Breathing H2S also induces a rapidly reversible reduction of metabolic rate at either body temperature.

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