Spine：女性脊柱侧凸与瘦素浓度偏低有关

南京大学医学院附属鼓楼医院邱勇教授等科研人员的一项最新研究发现，特发性脊柱侧凸的女性患者有体型偏瘦、骨量偏低和体内瘦素浓度偏低等特点，其降低的瘦素浓度可能是联系体型偏瘦和骨量偏低之间关系的重要因素。这一研究成果近日刊登在世界脊柱外科学术刊物《脊柱》（Spine）上。

特发性脊柱侧凸是好发于青春期的一种脊柱畸形，以女孩多见，发病年龄一般在10岁～16岁。瘦素作为青春期前后，尤其是女孩生长发育过程中非常重要的激素，参与调节青春期生长发育和骨代谢等多种过程。邱勇教授等研究发现，患特发性脊柱侧凸的女性大多体型偏瘦，且骨量偏低，推测这类患者可能存在异常的生长发育或异常的激素代谢特征。他们利用酶联免疫分析方法检测特发性脊柱侧凸女性患者的体内瘦素浓度，发现其外周血瘦素浓度明显低于同龄健康女孩，约相当于后者的一半水平。特发性脊柱侧凸患者体内的低瘦素水平与患者体型偏瘦、骨量偏低的临床特点关系密切，降低的外周血瘦素浓度可能是联系体型偏瘦和骨量偏低之间关系的重要因素。（来源：健康报刘宁春杨丽佳）

生物谷推荐原始出处：

（Spine），32(24):2703-2710，Qiu, Yong，Qian, Bangping

Decreased Circulating Leptin Level and Its Association With Body and Bone Mass in Girls With Adolescent Idiopathic Scoliosis.

Qiu, Yong MD; Sun, Xu PhD; Qiu, Xusheng PhD; Li, Weiguo PhD; Zhu, Zezhang MD; Zhu, Feng MD; Wang, Bin MD; Yu, Yang MD; Qian, Bangping MD

Abstract:
Study Design. A prospective study was designed to investigate the circulating leptin level in girls with adolescent idiopathic scoliosis (AIS).

Objective. To determine the circulating leptin levels in AIS girls, and to investigate its associations with body mass and bone mass.

Summary of Background Data. Abnormal growth pattern and osteopenia have been well documented in AIS patients throughout the peripubertal growth period. Leptin has been shown to regulate the growth of the whole body and bone particularly during childhood and adolescence. However, the circulating level of leptin, the relationships between leptin and lower body mass, and the relationships between leptin and lower bone mass in AIS patients remain unclear.

Methods. One hundred twenty AIS girls and 80 healthy controls were recruited in this study. Measurements of anthropometry and circulating leptin were performed both in AIS and non-AIS girls. Evaluations of curve severity and measurements of bone mineral content/density (BMC/BMD) were performed only in AIS girls. The anthropometric data and circulating leptin levels were compared between older AIS girls and controls. The relationships between leptin and age, menstrual status, body weight, height, body mass index (BMI), Risser sign, curve magnitude, and BMC/BMD were analyzed in AIS girls.

Results. Compared with healthy controls, an abnormal growth pattern (higher corrected height, lower weight, and lower BMI), and a marked decrease of circulating leptin were found in AIS girls, even after the adjustment for age and menstrual status. Positive correlations were found between leptin and age, menstrual status, body weight, height, BMI, and Risser sign. No significant correlation was found between leptin and curve magnitude. There was no significant difference in age at menarche between menstruating AIS and non-AIS girls, though an inverse correlation was observed between leptin and the age at menarche. The relationship between leptin and BMC/BMD remained significantly positive after controlling for age and menstrual status, although it was not independent of body weight or BMI.

Conclusion. A marked decrease of circulating leptin was observed in the current study. There was an association between leptin and body weight, BMI, other growth parameters, and BMC/BMD. This correlation suggests that leptin might play an important role in the lower body and bone mass in AIS girls.