AJH：血压水平可预测心血管病危险
北京阜外医院顾东风等研究发现，中国成年人中，血压与心血管病危险呈强烈、线性、独立相关。研究论文发表在《美国高血压杂志》上。
该全国代表性队列研究纳入了我国169871名40岁或以上的男性和女性。研究者分析了该人群基线时(1991年)的血压水平及相关指标，并在1999-2000年进行随访，统计该人群的心血管病危险，随访率93.4%。
结果表明，经过对年龄、性别、吸烟和饮酒情况、体力活动情况、体质指数、教育水平、地理区域、城市化水平、糖尿病病史时间的校正，血液收缩压和舒张压与心血管病、冠心病和卒中的危险呈强烈、线性相关。以心血管病为例，相比于血压水平(以“收缩压/舒张压”表示)低于110/75 mmHg者，血压水平分别为110~119/75~79 mmHg、120~129/80~84 mmHg、130~139/85~89 mmHg、140~159/90~99 mmHg、160~179/100~109 mmHg和不低于180/110 mmHg的人群，心血管病相对危险(RR)分别为1.09、1.25、1.49、2.15、3.01和4.16。与舒张压水平升高相比，收缩压水平升高与更高的心血管病危险相关。心血管病危险与高血压的相关性在各年龄、性别、体重人群中都存在。
研究者认为，血压与心血管病的强线性相关性在中国成年人中普遍存在，收缩压高是心血管病的有力预测因子。（来源：中国医学论坛报 静如）
生物谷推荐原始出处：
（American Journal of Hypertension），doi:10.1038/ajh.2007.59，Dongfeng Gu, Jiang He
Blood Pressure and Risk of Cardiovascular Disease in Chinese Men and Women
Dongfeng Gu1, Tanika N. Kelly2, Xigui Wu1, Jing Chen2,3, Xiufang Duan1, Jian-Feng Huang1, Ji-Chun Chen1, Paul K. Whelton4 and Jiang He2,3
- 1Department of Evidence Based Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Diseases, Beijing, China
- 2Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
- 3Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA
- 4The President's Office, Loyola University Medical Center, Chicago, Illinois, USA
Abstract
Background
We examined the relationship between systolic and diastolic blood pressure (BP) and the incidence of cardiovascular disease (CVD) in a nationally representative cohort of 169,871 men and women 
40 years of age in China.
Methods
Data on BP and other variables were obtained at a baseline examination in 1991 using standard protocols. Follow-up evaluation was conducted in 1999–2000, with a response rate of 93.4%.
Results
After adjustment for age, sex, cigarette smoking, alcohol consumption, physical activity, body mass index, education, geographic region, urbanization, and time-dependent history of diabetes, a strong and linear association between both systolic and diastolic BP and incidence of CVD, coronary heart disease and stroke were observed (all P < 0.0001). For example, the relative risks (95% confidence interval (CI)) of CVD incidence were 1.09 (1.00–1.18), 1.25 (1.16–1.35), 1.49 (1.38–1.62), 2.15 (1.99–2.31), 3.01 (2.78–3.27), and 4.16 (3.84–4.51) for those with systolic/diastolic BP of 110–119/75–79, 120–129/80–84, 130–139/85–89, 140–159/90–99, 160–179/100–109, and 180/110 mm Hg compared to those with BP <110/75 mm Hg. Increases in systolic BP were associated with a greater risk of CVD compared to corresponding increases in diastolic BP. The linear trend for increased CVD risk being related to higher BP levels was observed in all subgroups of gender, age, body weight, and cigarette smoking.
Conclusions
Our results indicate that there is a strong, linear, and independent relationship between BP levels and the risk of CVD in Chinese adults. Systolic BP is a stronger predictor of CVD risk compared to diastolic BP.
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