关于人类基因组数据和预测信息的可视化技术
文章原名为：Visualizing the genome techniques for presenting human genome data and annotations这是文章的原稿。下面是文章的摘要。
Background
In order to take full advantage of the newly available public human genome sequence
data and associated annotations, biologists require visualization tools ("genome
browsers") that can accommodate the high frequency of alternative splicing in human
genes and other complexities.
Results
In this article, we describe visualization techniques for presenting human genomic
sequence data and annotations in an interactive, graphical format. These techniques
include: one-dimensional, semantic zooming to show sequence data alongside gene
structures; color-coding exons to indicate frame of translation; adjustable, moveable
tiers to permit easier inspection of a genomic scene; and display of protein
annotations alongside gene structures to show how alternative splicing impacts
protein structure and function. These techniques are illustrated using examples from
two genome browser applications: the Neomorphic GeneViewer annotation tool and
ProtAnnot, a prototype viewer which shows protein annotations in the context of
genomic sequence.
Conclusion
By presenting techniques for visualizing genomic data, we hope to provide interested
software developers with a guide to what features are most likely to meet the needs of
biologists as they seek to make sense of the rapidly expanding body of public
genomic data and annotations.
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