Science：科学家将利用DNA检测技术诊断个人是否患心脏病
据英国《每日电讯》报道，美国的科学家们3日透露，他们近期准备通过DNA检测技术来诊断一个人是否会因为遗传因素影响患上心脏病。
据悉，基因技术研究人员已经鉴别出了一系列可能引发冠心病和心脏病的基因。而这一检测技术可以确定哪些人患心脏病的可能性高，以便于他们能够改变一些生活习惯。
据报道，这项基因检测技术的研究共研究了约4万人的基因组成，发现人类的基因序列如果有某处“错误”就会使人患心脏病的危险猛增。
研究发现，总体来说，约25%的人的体内基因都会出现这样的错误。对于这些人，他们患上心脏病的危险比没有基因序列“错误”的人要高出30%至60%。
研究同时也发现，欧洲人约有五分之一患心脏病和三分之一患有早搏的人是由于DNA的因素导致的。
来自加拿大渥太华大学的鲁斯-麦佛逊(Ruth Mcpherson)博士和来自德克萨斯州西南医学院的约翰森-科恩（Jonathan Cohen）近日将这一研究成果发表在了《科学》杂志上。基于这一研究，基因解码机构（deCODE）主任凯里-斯蒂芬森(Kari Stefansson)表示，将计划使用DNA检测技术来诊断一个人是否会因为遗传因素影响患上心脏病。
据悉，仅在英国，每年因为心脏病而死的人数就达到了20万。
原始出处:
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Published Online May 3, 2007 Science DOI: 10.1126/science.1142447 |
Reports
Submitted on March 12, 2007
Accepted on April 24, 2007
A Common Allele on Chromosome 9 Associated with Coronary Heart Disease
1 Division of Cardiology, University of Ottawa Heart Institute, Ottawa K1Y4W7, Canada.
2 Donald W. Reynolds Cardiovascular Clinical Research Center and the Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
3 Perlegen Sciences, Mountain View, CA 94043; USA.
4 Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA & U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA.
5 Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen DK-2100, Denmark.
6 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA.
7 Human Genetics Center and Institute for Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.
8 Donald W. Reynolds Cardiovascular Clinical Research Center and the Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute at the University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
9 Donald W. Reynolds Cardiovascular Clinical Research Center and the Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Center for Human Nutrition
* To whom correspondence should be addressed.
Ruth McPherson , E-mail: rmcpherson@ottawaheart.ca
Jonathan C. Cohen , E-mail: jonathan.cohen@utsouthwestern.edu
Coronary heart disease (CHD) is a major cause of death in Western countries. Here we used genome-wide association scanning to identify a 58 kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (n> 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension or diabetes. Homozygotes for the risk allele comprise 20-25% of Caucasians and have a ~30-40% increased risk of CHD.
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