B细胞发育的关键信号-- Rac1 and Rac2

Critical Roles for Rac1 and Rac2 GTPases in B Cell Development and Signaling

Marita J. Walmsley,^1* Steen K. T. Ooi,^1* Lucinda F. Reynolds,¹ Susan Harless Smith,² Sandra Ruf,¹ Anne Mathiot,¹ Lesley Vanes,¹ David A. Williams,³ Michael P. Cancro,² Victor L. J. Tybulewicz¹

The Rac1 guanosine triphosphatase (GTPase) has been implicated in multiple cellular functions, including actin dynamics, proliferation, apoptosis, adhesion, and migration resulting from signaling by multiple receptors, including the B cell antigen receptor (BCR). We used conditional gene targeting to generate mice with specific Rac1 deficiency in the B cell lineage. In the absence of both Rac1 and the highly related Rac2, B cell development was almost completely blocked. Both GTPases were required to transduce BCR signals leading to proliferation, survival and up-regulation of BAFF-R, a receptor for BAFF, a key survival molecule required for B cell development and maintenance.

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