Nature Immunology ：血液干细胞有神经冲动
生物谷报道：研究人员在9月在线出版的《自然—免疫学》期刊上报告：血液干细胞在神经细胞信号的作用下会被激活。
Tsvee Lapidot和同事在实验中发现，骨髓干细胞表达出了多巴胺受体。在压力状态下释放的神经传递素能诱发血细胞分化，并从保护它们的骨髓环境中迁移出来。用多巴胺或其他神经传递素对小鼠进行治疗，会导致小鼠骨髓和血液循环中的干细胞数量的增加。同样地，刺激人体骨髓细胞中的神经传递素也能增加它们移植到“人源化鼠”中的可能性，这种“人源化鼠”的免疫系统用人体细胞进行了重组。
对于需要骨髓移植的治疗来说，新发现可用于提高治疗效率的研究。（科学时报）
原始出处:
Nature Immunology
Published online: 9 September 2007 | doi:10.1038/ni1509
Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling
Asaf Spiegel1, Shoham Shivtiel1, Alexander Kalinkovich1, Aya Ludin1, Neta Netzer1, Polina Goichberg1, Yaara Azaria1, Igor Resnick2, Izhar Hardan3, Herzel Ben-Hur4, Arnon Nagler3, Menachem Rubinstein5 & Tsvee Lapidot1
Abstract
Catecholamines are important regulators of homeostasis, yet their functions in hematopoiesis are poorly understood. Here we report that immature human CD34+ cells dynamically expressed dopamine and 
2-adrenergic receptors, with higher expression in the primitive CD34+CD38lo population. The myeloid cytokines G-CSF and GM-CSF upregulated neuronal receptor expression on immature CD34+ cells. Treatment with neurotransmitters increased the motility, proliferation and colony formation of human progenitor cells, correlating with increased polarity, expression of the metalloproteinase MT1-MMP and activity of the metalloproteinase MMP-2. Treatment with catecholamines enhanced human CD34+ cell engraftment of NOD-SCID mice through Wnt signaling activation and increased cell mobilization and bone marrow Sca-1+c-Kit+Lin- cell numbers. Our results identify new functions for neurotransmitters and myeloid cytokines in the direct regulation of human and mouse progenitor cell migration and development.
- Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
- Department of Bone Marrow Transplantation & Cancer Immunotherapy, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
- Department of Hematology & Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel.
- Assaf Haroffe Medical Center, Tsrifin 70300, Israel.
- Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel.
Correspondence to: Tsvee Lapidot1 e-mail: tsvee.lapidot@weizmann.ac.il
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