Nat Immuo：IRF4对B细胞成熟至关重要
B细胞是一种免疫细胞，它的成熟过程对其行使功能来说至关重要。研究人员在7月出版的《自然—免疫学》期刊上报告说，他们鉴别出一种对B细胞成熟过程来说至关重要的蛋白质。
B淋巴细胞产生抗体，这种抗体分子能给入侵的病原体贴上标签，从而让免疫系统向它们发起进攻。B淋巴细胞还能改变抗体的类型，让它们适应不同类型的病原体。
Riccardo Dalla-Favera和同事发现，如果缺少一种名为 IRF4的分子，B淋巴细胞就无法转换抗体的类型。这些结果表明：IRF4对B淋巴细胞实施免疫功能来说至关重要。此外，因为部分B细胞癌症患者含有过量的 IRF4，这些结果也许有助于研究人员弄清楚为什么会出现某种类型的癌症。
原始出处：
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nature Immunology 7, 773 - 782 (2006)
作者其它文章：
Selected Publications
Niu, H., Ye, B-H., and Dalla-Favera, R. Antigen-Receptor Signaling Induces MAP Kinase-Mediated Phosphorylation and Degradation of the BCL-6 Transcription Factor. Genes & Dev., 12(13): 1953-1961 (1998).
Pasqualucci, L., Migliazza, A., Fracchiolla N., William C., Neri, A., Baldini, L., Chaganti, R.S.K., Klein, U., Kueppers, R., Rajewsky, K., Dalla-Favera, R. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci (USA), 95: 11816-11821, (1998).
Wu, K.-J., Dalla-Favera, R. Direct activation of telomerase reverse transcriptase (hTERT) gene transcription by c-MYC. Nature Genetics, 21: 220-224 (1999). Wu, K-J., Polack, A., Dalla-Favera, R. (1999).
Wu, K.-J., Polack, A., Dalla-Favera, R. Coordinated regulation of iron-controlling genes, H-Ferritin and IRP2, by c-Myc. Science, 283: 676-679 (1999).
Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RS, Kuppers R, Dalla-Favera R. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature, 19:341-346 (2001).
Klein, U., Tu, Y., Stolovitzky, G.A., Mattioli, M., Cattoretti, G., Husson, H., Freedman, A., Inghirami, G., Cro, L., Baldini, L., Neri, A., Califano, A., Dalla-Favera, R. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogenous phenotype related to memory B cells. J. Exp Med, 97: 2098-2104 (2001) (Supplementary Data) 
Klein, U., Gloghini, A., Gaidano, G., Chadburn, A., Cesarman, E., Dalla-Favera, R., Carbone, A. Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts. Blood First Edition Paper, prepublished online January 16, 2003 (Supplementary Data)
Klein, U., Tu, Y., Stolovitzky, G.A., Keller, J.L., Haddad Jr., J., Miljkovic, V., Cattoretti, G., Califano, A., Dalla-Favera, R. Transcriptional Analysis of the B-Cell Germinal Center Reaction. Proc. Acad. Natl. Sci. U. S. A. 100:2639-2644, 2003 (Supplementary Data)
Küppers, R., U. Klein, I. Schwering, V. Distler, A. Bräuninger, G. Cattoretti, Y. Tu, G.A. Stolovitzky, A. Califano, M.-L. Hansmann, and R. Dalla-Favera. Identification of Hodgkin and Reed-Sternberg Cell-Specific Genes by Gene Expression Profiling. J. Clin. Invest. 111:529-537, 2003 (Supplementary Data)
Basso, K., Liso, A., Tiacci, E., Benedetti, R., Pulsoni, A., Foa, R., Di Raimondo, F., Ambrosetti, A., Califano, A., Klein, U., Dalla-Favera, R., Falini, B. Gene expression profiling of hairy cell leukemia reveals a phenotype related to memory B cells with altered expression of chemokine and adhesion receptors. J. Exp. Med. 199 (1): 59-68. (Supplementary Data)
Basso, K., Klein, U., Niu, H., Stolovitzky G.A., Tu, Y., Califano, A., Cattoretti, G., and Dalla-Favera, R. Tracking CD40 signaling during germinal center development Blood 104 (13): 4088-4096 2004. (Supplementary Data)
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