生物谷报道:基因治疗成为近两年来最热门的话题,在Pubmed搜索有23000多篇文献,Nature系列杂志中还有一本专门的杂志《基因治疗》。尤其在癌症治疗上,基因治疗一直处于研究最前沿,前不久国内第一个基因药物p53也问世了,表明基因治疗从基础研究到临床的一大步跳跃。然而我们也必需要了解基因治疗可能的副作用。这是近期有关基因治疗的最新研究概括以及国外最新动态,同时这些综述也反应当时基因治疗的不成熟的状态。文献多为免费提供。
Cancer gene therapy using tumour suppressor genes
I A McNeish, S J Bell and N R Lemoine
Noninvasive imaging of gene therapy in living subjects
J J Min and S S Gambhir
Gene therapy for severe combined immunodeficiency
H B Gaspar, S Howe and A J Thrasher
Parkinson's disease
E A Burton, J C Glorioso and D J Fink
Gene therapy of lysosomal storage disorders
S H Cheng and A E Smith
Adenoviral vectors
J A St George
Gene therapy for the hemophilias
C E Walsh
Gene therapy in organ transplantation
J Bagley and J Iacomini
Naked DNA gene transfer and therapy
H Herweijer and J A Wolff
Therapeutic angiogenesis for limb and myocardial ischemia
T A Khan, F W Sellke and R J Laham
Alpha-1 antitrypsin
A A Stecenko and K L Brigham
Nonviral vectors
T Niidome and L Huang
Post-intervention vessel remodeling
J Rutanen, H Puhakka and S Ylä-Herttuala
Cystic fibrosis
U Griesenbach, S Ferrari, D M Geddes and E W F W Alton


