生物谷报道：今天刚刚出版的Science报道：不同亚型的HNF是控制胰腺和肝脏发育过程中基因表达的关键因子。这一研究成果是真正转录组学文章。
The transcriptional regulatory networks that specify and maintain human tissue diversity are largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation combined with promoter microarrays to identify systematically the genes occupied by the transcriptional regulators HNF1
, HNF4, and HNF6, together with RNA polymerase II, in human liver and pancreatic islets. We identified tissue-specific regulatory circuits formed by HNF1, HNF4, and HNF6 with other transcription factors, revealing how these factors function as master regulators of hepatocyte and islet transcription. Our results suggest how misregulation of HNF4 can contribute to type 2 diabetes.
Original article:
Control of Pancreas and Liver Gene Expression by HNF Transcription Factors
Duncan T. Odom, Nora Zizlsperger, D. Benjamin Gordon, George W. Bell, Nicola J. Rinaldi, Heather L. Murray, Tom L. Volkert, Jörg Schreiber, P. Alexander Rolfe, David K. Gifford, Ernest Fraenkel, Graeme I. Bell, and Richard A. Young
Science Feb 27 2004: 1378-1381.
