生物谷报道：今天刚刚出版的Science报道了这一成果，方法学并无新意，但结果为揭示有丝分裂的机理有很大的参考价值。
A Genome-Wide Screen Identifies Genes Required for Centromeric Cohesion
Adele L. Marston, Wai-Hong Tham, Hiral Shah, Angelika Amon
Science, Vol. 303, Issue 5662, 1367-1370, February 27, 2004
During meiosis, two chromosome segregation phases follow a single round of DNA replication.
We identified factors required to establish this specialized cell cycle by examining meiotic chromosome
segregation in a collection of yeast strains lacking all nonessential genes. This analysis revealed Sgo1, Chl4,
and Iml3 to be important for retaining centromeric cohesin until the onset of anaphase II. Consistent with this role,
Sgo1 localizes to centromeric regions but dissociates at the onset of anaphase II. The screen described here provides
a comprehensive analysis of the genes required for the meiotic cell cycle and identifies three factors important for
the stepwise loss of sister chromatid cohesion.
Original article:
A Genome-Wide Screen Identifies Genes Required for Centromeric Cohesion
Adele L. Marston, Wai-Hong Tham, Hiral Shah, and Angelika Amon
Science Feb 27 2004: 1367-1370.
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