ATP产生机理的揭示

生物谷报道：ATP产生一直存在许多假说，近期一系列研究从结构、功能和动力学等方面全面揭示了ATP产生的机制。其中一篇方面成为《自然结构和分子生物学杂志》的封面文章。

The enzyme ATP synthase produces the universal energy molecule ATP in organisms ranging from bacteria to humans. Two papers in February's Nature Structural and Molecular Biology by Manuel Diez et al. and Takayuki Nishizaka et al. report major advances in understanding how this tiny motor works. Demonstrated for the first time is the direction of proton-gradient-driven rotation, and the generation of ATP from forced rotation of the motor. Alan Senior and Joachim Weber review these findings in a News and Views article.

news and views
Happy motoring with ATP synthase
A. E. SENIOR AND J. WEBER
Nature Structural and Molecular Biology 11, 110; February 2004
| Abstract | Full Text (HTML/PDF) |

articles
Proton-powered subunit rotation in single membrane-bound F₀F₁-ATP synthase
M. DIEZ et al.
Nature Structural and Molecular Biology 11,135; February 2004
| Abstract | Full Text (HTML/PDF) |

articles
Chemomechanical coupling in F₁-ATPase revealed by simultaneuous observation of nucleotide kinetics and rotation
T. NISHIZAKA et al.
Nature Structural and Molecular Biology 11, 142; February 2004
| Abstract | Full Text (HTML/PDF) |