内质网(endoplasmicreticulum ,ER)广泛存在于真核细胞中,是调节蛋白质合成及合成后折叠、聚集的场所,是调节细胞的应激反应及细胞钙水平的场所,也是胆固醇、类固醇及许多脂质合成的场所。ER应激在细胞凋亡中起重要作用,现就ER应激在细胞中的作用、ER应激与Ca2 + 水平的调节及与相关凋亡蛋白之间的关系等方面进行综述。
Endoplasmic reticulum(ER) extensively exists in eukaryocytes, where protein synthesis, and fold, recruitment are regulated after protein synthesis, the stress action of cell and calcium level in cell are adjusted, as well as cholesterol, steroids and most of lipid are synthesized. ER stress plays an important role in the cell apoptosis. This article reviews the role of ER stress, the regulation of ER stress and the level of Ca 2+ and the relation to apoptotic proteins.
