细胞分化的时钟控制机理

Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo

Science, Vol. 302, Issue 5643, 255-259, October 10, 2003
Takuya Matsuo,^1,2* Shun Yamaguchi,^1* Shigeru Mitsui,¹ Aki Emi,¹ Fukuko Shimoda,¹ Hitoshi Okamura¹

Cell division in many mammalian tissues is associated with specific times of day, but just how the circadian clock controls this timing has not been clear. Here, we show in the regenerating liver (of mice) that the circadian clock controls the expression of cell cycle–related genes that in turn modulate the expression of active Cyclin B1-Cdc2 kinase, a key regulator of mitosis. Among these genes, expression of wee1 was directly regulated by the molecular components of the circadian clockwork. In contrast, the circadian clockwork oscillated independently of the cell cycle in single cells. Thus, the intracellular circadian clockwork can control the cell-division cycle directly and unidirectionally in proliferating cells.

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