Opportunities and Challenges:A Focus on Future Stem Cell Applications

生物谷

The makings of future news headlines about tomorrow's life saving therapies starts in the biomedical research laboratory. Ideas abound; early sucesses and later failures and knowledge gained from both; the rare lightning bolt of an unexpected breakthrough discovery — this is a glimpse of the behind the scenes action of some of the world's most acclaimed stem cell scientists' quest to solve some of the human body's most challenging mysteries.

Stem cells — what lies ahead? The following chapters explore some of the cutting edge research featuring stem cells. Disease and disorders with no therapies or at best, partially effective ones, are the lure of the pursuit of stem cell research. Described here are examples of significant progress that is a prologue to an era of medical discovery of cell-based therapies that will one day restore function to those whose lives are now challenged every day — but perhaps in the future, no longer.

Contents
(PDF files, Please download your harddish and then read them)

	Preface
	Executive Summary
	Chapter 1: The Stem Cell
	Chapter 2: The Embryonic Stem Cell
	Chapter 3: The Human Embryonic Stem Cell and The Human Embryonic Germ Cell
	Chapter 4: The Adult Stem Cell
	Chapter 5: Hematopoietic Stem Cells
	Chapter 6: Autoimmune Diseases and the Promise of Stem Cell-Based Therapies
	Chapter 7: Stem Cells and Diabetes
	Chapter 8: Rebuilding the Nervous System with Stem Cells
	Chapter 9: Can Stem Cells Repair a Damaged Heart?
	Chapter 10: Assessing Human Stem Cell Safety
	Chapter 11: Use of Genetically Modified Stem Cells in Experimental Gene Therapies

	Appendix A: Early Development
	Appendix B: Mouse Embryonic Stem Cells
	Appendix C: Human Embryonic Stem Cells and Embryonic Germ Cells
	Appendix D: Stem Cell Tables
		i. Published Reports on Isolation and Differentiation of Mouse Stem Cells
		ii. Published Reports on Isolation and Differentiation of Human Fetal Tissue Germ Cells
		iii. Published Reports on Isolation and Differentiation of Human Embryonic Stem Cells
		iv. Published Reports on Isolation and Differentiation of Human Embryonic Carcinoma Stem Cells
		v. Published Reports on Isolation and Differentiation of Human Adult Stem Cells
		vi. References
	Appendix E: Stem Cell Markers
		i. Markers: How Do Researchers Use Them to Identify Stem Cells?
		ii. Commonly Used Markers to Identify Stem Cells and Characterize Differentiated Cell Types
	Appendix F: Glossary and Terms
		i. Glossary
		ii. Terms
	Appendix G: Informational Resources
		i. Persons Interviewed
		ii. Special Contributions
		iii. Acknowledgments

Reference citations of this report should use the following:

Stem Cells: Scientific Progress and Future Research Directions.
Department of Health and Human Services. June 2001. http://www.nih.gov/news/stemcell/scireport.htm