Nature：蛋白质B-crystallin在多发性硬化症中所起作用

生物谷

生物谷报道：蛋白质B-crystallin主要存在于眼睛的晶状体中，它在多发性硬化中所发生的炎症和损伤的发展过程中可能是关键的“引爆点”。过去，人们知道它是多发性硬化患者体内一个主要免疫目标。现在，用小鼠所做的研究工作表明，该蛋白在一个多发性硬化模型中还扮演一个保护角色。当将其注射进实验鼠体内时，它起一种消炎和神经保护因子的作用，并且还能使瘫痪发生逆转。该研究成果发表在最新一期的《自然》杂志上。

原文出处：

Nature Volume 448 Number 7152

Protective and therapeutic role for B-crystallin in autoimmune demyelination p474

Shalina S. Ousman, Beren H. Tomooka, Johannes M. van Noort, Eric F. Wawrousek, Kevin O'Conner, David A. Hafler, Raymond A. Sobel, William H. Robinson & Lawrence Steinman

doi:10.1038/nature05935

First paragraph | Full Text | PDF (1,046K) | Supplementary information

作者简介：

Lawrence Steinman

Academic Appointments

Appointment

Organization

ProfessorNeurology & Neurological Sciences

ProfessorPediatrics

Professor (By courtesy)Genetics

Research Interests

Our laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.

Publications

§Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L "Peroxisome proliferator-activated receptor (PPAR){alpha} expression in T cells mediates gender differences in development of T cell-mediated autoimmunity." J Exp Med 2007; More »

§Steinman L, "A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage." Nat Med 2007; 13: 2: 139-45 More »

§Kanter JL, Narayana S, Ho PP, Catz I, Warren KG, Sobel RA, Steinman L, Robinson WH "Lipid microarrays identify key mediators of autoimmune brain inflammation." Nat Med 2006; 12: 1: 138-143 More »

§Dunn SE, Youssef S, Goldstein MJ, Prod'homme T, Weber MS, Zamvil SS, Steinman L "Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin." J Exp Med 2006; 203: 2: 401-12 More »

§Langer-Gould A, Steinman L "What went wrong in the natalizumab trials?" Lancet 2006; 367: 9512: 708-10 More »

相关基因：

CRYAB

Official Symbol CRYAB and Name: crystallin, alpha B [Homo sapiens]
Other Aliases: CRYA2, CTPP2, HSPB5
Other Designations: heat-shock 20 kD like-protein
Chromosome: 11; Location: 11q22.3-q23.1
Annotation: Chromosome 11, NC_000011.8 (111284560..111287683, complement)
MIM: 123590
GeneID: 1410