Nature：内质网的非蛋白通道假设
生物谷：一种蛋白通道被假设为内质网（ER）的一个构成部分，来解释误折叠蛋白和非包裹病毒能够通过ER进入细胞质这一事实。酵母中的Der1蛋白和其他真核细胞中的Derlins是有可能在这样的转位通道（dislocon）中发挥功能的蛋白类型的例子。但Hidde Ploegh在本刊非定期推出的“假设”（Hypothesis）栏目中撰文提出另一个机制，该机制也许能够无需一个基于蛋白的通道而对上述事实做出解释。按照这个机制，由类脂重排诱发而打开的一个逃逸门可让蛋白和病毒都通过ER。（生命经纬）
原始出处:
Nature 448, 435-438 (26 July 2007) | doi:10.1038/nature06004
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum
Hidde L. Ploegh1
- Whitehead Institute, MIT Department of Biology, Cambridge, Massachusetts 02142, USA
Correspondence to: Hidde L. Ploegh1 Correspondence should be addressed to H.L.P. (Email: ploegh@wi.mit.edu).
Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in (glyco)protein quality control.
图：Biogenesis of lipid droplets and a model for their involvement in escape of macromolecules and viruses from the ER.
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