2003-11-21 15:48:00

数据库：GOA

佚名

GOA是一个由EBI开发的数据库，其目标是提供一个从基因产物到GO标识的链接资源。我们已经很多次介绍过GO了，简要来说，GO的目标就是产生一个可以动态控制的词表来标识基因产物，即使该基因或蛋白在细胞内的作用或功能仍然处于知识积累阶段并且在不断更新中。在GOA计划中，该词表将被应用到Swiss-Prot，TrEMBL and Ensemble中的非冗余蛋白数据集中。编者认为GOA在功能基因组研究中将发挥重要作用，那么我们能利用GOA作哪些工作呢，下面是GOA开发者举的一些例子：

access functional information for the human proteome (GOA-Human) or for any protein in EBI's protein databases (GOA-SPTR).
ask questions such as ''find me all proteins involved in apoptosis(GO:0006915) but not involved via death domain receptors (GO:0008625), and then find their coding sequences'.
use GO-Slim to summarize the biological attributes of a proteome, compare proteomes, or find out what proportion of a proteome is involved in eg. 'transport'.
incorporate our manual annotation into your own databases to enhance your dataset, or use it to validate your automated way of deriving information about gene function.
map GO terms to your own datasets; for example, our GO mapping to InterPro entries (InterPro2GO) can be used to annotate mass spectrometry or microarray data.
find the location of human genes mapped to a particular GO term using ensembl GO-View.