作者单位：陈礼刚 成都军区总医院神经外科 610083 四川省成都市
高立达 华西医科大学附一院神经外科
参考文献
1 Tuszynski MH,Peterson DA,Jadodhara Rag,et al.Fibroblastsgenetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord.Exp Neurol,1994,126:1.
2 Tuszynski MH,Gabriel K,Gage FH,et al.Nerve growth factor delivery by gene transfer induce differential outgrowth of sensory,motor and noradrenergeic neurites after spinal cord injury.Exp Neurol,1996,127:157.
3 Gage FH,Kawaja MD,Fisher LJ.Genetically modified cells:applications for intracerebral grafting.TINS,1991,14（8）:328.
4 Tuszynski MH,Gage.Maintaining the neuronal phenotype after injury in the adult CNS neurotrophic factors,axonal growth substraters and gene therapy.Molecular Neurobiology,1995,10:151.
5 Karpati G,Lochmuler H,Naibantoglu J,et al.The principles of gene tharapy for hte nervous system.TINS,1996,19（2）：49.
6 Karen SC,Fred HG.Somatic gene transfer of NGF to the aged brain behavioural and mophological amelioration.J Neurosci,1995,15:2811.
7 Cao L,Zhengac,Ahao YC,et al.Gene therapy of parkinson disease mode rat by direct injection of plasmid DNA,Lipofection complex.Human Gene Therapy,1995,6:1497.
8 Boussif O,lezoualch F,Zanta MA,et al.Versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo polyethyenimine.Proc Nate Acad Sci USA,1995,92:7277.
9 Tuszynski MH,Meyers,Nakahara Y,et al.Fibroblasts and schwann cells genetically modified to produce neurotrophic factors induce robust neuritic growth after transplantation to the spinal cord.Soc Neurosci Abstr,1994,20:10.
10 徐群渊，田竟生，张进禄,等.体外转基因肌细胞植入帕金森病模型大鼠的研究.中华外科杂志，1997,20:10.
11 Blesch A,Tuszynski MH,Robust growth of chronically injured spinal cord axon induced by grafts of genatically.Modifed NGF-secreting cells.Exp Neurol,1997;148.
12 陈礼刚，高立达，毛伯镛，等.pSVPoMcat微基因修饰雪旺氏细胞脊髓内移植对损伤脊髓再生的影响.中国修复重建外科杂志，1998,12（5）:257.
13 陈礼刚，高立达，曾凡俊，等.移植pSVPoMcat微基因修饰SC对脊髓损伤后细胞凋亡的作用.中华创伤杂志，1998，14（3）：165.
14 陈忠平.微囊包膜神经系统细胞移植.国外医学神经病神经外科学分册，1995,22（3）:143.
15 Nikknak G,Cunningham MG,Jodicke A,et al.Improved grafted survival and striated reinneration by microtransplantation of fetal nigral cell suspension in the rat parkinson model.Brain Res,1994,633:133.
