徐彬 柏树令 2004-8-2 20:29:13 解剖科学进展 2000年第3期第6卷 原著
摘要：在胚胎发育过程中，TGF-βⅡ受体是TGF-β调节牙齿形成通路的关键因素．TGF-β2或EGF表达不足时会严重影响牙齿的发育。TGF-βⅡ受体失活改变了内源性TGF-β信号系统对器官上皮细胞增生的负向调节效应，从而刺激了牙的胚胎发育。
Regulation of TGF on the Development of Tooth
xu Bin,Bai Shuling(Department of Anatomy, China Medical University Shenyang 110001)
Abstract：TGF-β Ⅱ R is key point for tGF-β regulating the formation of tooth. Under expression of TGF-β2 or EGF severely affected tooth development. Our results demonstrated that abrogation of tGF-β Ⅱ R Stimulated embryonic tooth development through changing the negative regulation of endogeneous tGF-β signaling upon enamel epithelial cell proliferation.
Keywords：TGF regulation; tooth development; antisense ODN
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