生物谷报道：本周Science发表了这篇文章，揭示了脂肪激素Resistin是重要的餐后血糖调节因子，这一发现为解决糖尿病提供了良好的前景和曙光。
The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production. This is partly mediated by activation of adenosine monophosphate–activated protein kinase and decreased expression of gluconeogenic enzymes in the liver. The data thus support a physiological function for resistin in the maintenance of blood glucose during fasting. Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity.
Original article:
Regulation of Fasted Blood Glucose by Resistin
Ronadip R. Banerjee, Shamina M. Rangwala, Jennifer S. Shapiro, A. Sophie Rich, Ben Rhoades, Yong Qi, Juan Wang, Michael W. Rajala, Alessandro Pocai, Phillipp E. Scherer, Claire M. Steppan, Rexford S. Ahima, Silvana Obici, Luciano Rossetti, and Mitchell A. Lazar
Science Feb 20 2004: 1195-1198.
