CMAJ:年轻女性接种HPV疫苗和高风险的性行为之间或并无关联

生物谷   2014/12/10

2014年12月10日 讯 /生物谷BIOON/ --近日,一项发表于国际杂志Canadian Medical Association Journal上的研究论文中,来自加拿大皇后大学的科学家们通过研究发现,注射人乳头瘤病毒(HPV)疫苗似乎不会影响青年女性的性行为。HPV可以保护女性机体抵御四种类型的人乳头瘤病毒,人乳头瘤病毒是引发宫颈癌和肛门生殖器疣的原因。

研究者Smith说道,我们研究发现注射HPV疫苗似乎给予青年女性一种虚假的安全感,认为其注射疫苗后不会通过性传播疾病感染人乳头瘤病毒,从而使得青年女性陷入到高风险的性行为中。在接种HPV疫苗担心病毒通过性行为传播的风险会增加是毫无根据的。

文章中,研究人员对260493名年轻女性进行了一项队列研究,其中一半的研究对象(128712名)都具有接受安大略省政府资助的资格,研究人员在2007年8月和2008年9月对研究对象进行了HPV疫苗的接种策略,随后研究者对其进行跟踪研究直到参与对象上学到12年级(高三),研究结果发现,大约6%的女孩儿在10年级至12年级期间怀孕或者感染了性病,包括10187名个体怀孕及6259名个体患上了非HPV相关的性传播疾病。

研究者Levesque博士表示,接种HPV疫苗和程序化的管理都不会增加14至17岁间的青年女性怀孕的风险,同时也不会增加个体患非HPV相关的性病的风险;本文研究或许可以帮助医生及政策制定者来共同关注HPV疫苗的接种及个体的乱交行为。

自从2006年开始,HPV疫苗的接种已经在几乎100个国家得到了批准,其中就包括加拿大;许多国家都拥有一套HPV的接种程序来保护年轻女性在性活动之前免于HPV的感染。(生物谷Bioon.com)

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Effect of human papillomavirus (HPV) vaccination on clinical indicators of sexual behaviour among adolescent girls: the Ontario Grade 8 HPV Vaccine Cohort Study

Leah M. Smith, Jay S. Kaufman, Erin C. Strumpf, Linda E. Lévesque

Background: Suboptimal human papillomavirus (HPV) vaccine coverage in some jurisdictions is partly attributed to fears that vaccination may increase risky sexual behaviour. We assessed the effect of HPV vaccination on clinical indicators of sexual behaviour among adolescent girls in Ontario. Methods: Using Ontario's administrative health databases, we identified a population-based cohort of girls in grade 8 in the 2 years before (2005/06 and 2006/07) and after (2007/08 and 2008/09) implementation of Ontario's grade 8 HPV vaccination program. For each girl, we then obtained data on vaccine receipt in grades 8 and 9 and data on indicators of sexual behaviour (pregnancy and non–HPV-related sexually transmitted infections) in grades 10–12. Using a quasi-experimental method known as regression discontinuity, we estimated, for each outcome, the risk difference (RD) and relative risk (RR) attributable to vaccination and to program eligibility. Results: The cohort comprised 260 493 girls, of whom 131 781 were ineligible for the program and 128 712 were eligible. We identified 15 441 (5.9%) cases of pregnancy and sexually transmitted infection and found no evidence that vaccination increased the risk of this composite outcome: RD per 1000 girls –0.61 (95% confidence interval [CI] –10.71 to 9.49) and RR 0.96 (95% CI 0.81 to 1.14). Similarly, we found no discernible effect of program eligibility: RD per 1000 girls –0.25 (95% CI –4.35 to 3.85) and RR 0.99 (95% CI 0.93 to 1.06). The findings were similar when outcomes were assessed separately. Interpretation: We present strong evidence that HPV vaccination does not have any significant effect on clinical indicators of sexual behaviour among adolescent girls. These results suggest that concerns over increased promiscuity following HPV vaccination are unwarranted and should not deter from vaccinating at a young age.

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